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目的:探讨影响狼疮肾炎尿毒症患者预后的因素,为控制尿毒症的发生和发展提供依据。方法:通过随访方式追踪狼疮肾炎尿毒症患者的临床、实验室及治疗的资料,采用COX回归模型,进行单因素及多因素分析。结果:102例狼疮肾炎尿毒症患者中,有37例死亡(占36.3%),多因素分析显示血尿酸、Ccr、肾萎缩与否和血尿素氮对预后有显著影响,且为独立因素,而临床分型、性别、狼疮活动指数和血肌酐并不是影响预后的独立因素。结论:高水平的尿酸和血尿素氮为独立危险因素,而肾无萎缩和Ccr的维持有利于肾功能的改善。
Objective: To investigate the prognosis of patients with uremic lupus nephritis factors, to control the occurrence and development of uremia provide the basis. Methods: The clinical, laboratory and treatment data of patients with lupus nephritis uremic were followed up by follow-up. COX regression model was used to analyze single factor and multivariate analysis. Results: Of 102 patients with lupus nephritis, 37 died (36.3%). Multivariate analysis showed that serum uric acid, Ccr, renal atrophy and blood urea nitrogen had a significant effect on prognosis, and were independent factors. Clinical classification, sex, lupus activity index and serum creatinine were not independent prognostic factors. Conclusion: High levels of uric acid and blood urea nitrogen are independent risk factors, while no renal atrophy and maintenance of Ccr are good for renal function improvement.