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[目的]探讨某家具生产基地甲醛-苯联合污染与胎儿畸形的相关性,为降低胎儿出生缺陷提供依据。[方法]以2010年4月—2012年12月佛山市顺德区龙江医院分娩及经产前诊断有胎儿畸形的80例孕产妇,对其居住、工作环境进行甲醛、苯、甲苯、二甲苯浓度监测,并以同期正常儿的80例孕产妇的情况进行对比分析。[结果]胎儿畸形中排行前4位依次为:先天性心脏病15例(占18.75%)、耳畸形13例(占16.25%)、脑畸形13例(占16.25%)、足内外翻7例(占8.75%)。畸胎组孕产妇居住或工作环境甲醛、苯、甲苯、二甲苯的浓度分别为(1.15±0.35)、(0.44±0.18)、(1.28±0.35)、(2.18±0.34)mg/m3,均明显高于对照组(P<0.01);检测点超标率为96.25%～98.33%,明显高于正常组(P<0.01)。[结论]胎儿畸形可能与甲醛-苯污染相关。
[Objective] To investigate the correlation between formaldehyde-benzene combined pollution and fetal malformation in a furniture production base and provide the basis for reducing birth defects. [Methods] From April 2010 to December 2012, Shunde District Longjiang Hospital, Foshan City, delivery and prenatal diagnosis of fetal malformations of 80 pregnant women, their living, working environment for formaldehyde, benzene, toluene, xylene Concentration monitoring, and to normal children of the same period 80 cases of maternal comparative analysis. [Results] The top four fetal malformations ranked as follows: 15 cases (18.75%) of congenital heart disease, 13 cases (16.25%) of ear malformations, 13 cases (16.25%) of brain malformations, 7 cases of foot valgus (8.75%). The concentrations of formaldehyde, benzene, toluene and xylene in the teratogenic group living or working environment were (1.15 ± 0.35), (0.44 ± 0.18), (1.28 ± 0.35) and (2.18 ± 0.34) mg / m3 respectively (P <0.01). The over-standard rate of test points was 96.25% -98.33%, which was significantly higher than that of the control group (P <0.01). [Conclusion] Fetal deformity may be related to formaldehyde - benzene pollution.