Adverse environmental factors or prenatal insults may cause developmental and pathological changes in the brain[1]. Previous studies showed that a number of unfavorable prenatal factors might trigger the pathological changes of adult diseases such as hypertension and diabetes mellitus[2]. It is rational that inner-utero hypoxia could be a common problem of prenatal insults-induced development. Hence, this study focused on prenatal hypoxia (PH) during pregnancy.