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目的:探讨股前外侧皮瓣修复口腔颌面肿瘤切除后复合眶内容物缺失的上颌骨缺损的临床效果。方法:回顾性分析上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科，2013年1月至2020年9月收治的因口腔颌面部肿瘤行眶内容物剜除合并上颌骨缺损病例，均行股前外侧皮瓣修复，根据缺损类型，分为眼眶周围皮肤、鼻腔侧黏膜、口腔侧腭部黏膜均有缺损的口-鼻-眶复合缺损；眶内容物及口-鼻腔复合缺损；眶内容物及鼻腔-眼眶皮肤复合缺损；眶内容物及眼眶皮肤缺损。根据缺损类型及股前外侧皮瓣穿支数量，将皮瓣设计为3叶、双叶或单叶皮瓣，并决定是否行口鼻瘘封闭。术后根据患者口内条件，行赝复体修复。结果:研究共纳入29例，其中男19例，女10例，年龄23~82岁。8例为眶内容物及口-鼻-眶复合缺损，17例为眶内容物及口-鼻腔复合缺损，1例为眶内容物及鼻腔-眼眶皮肤复合缺损，3例为眶内容物及眼眶皮肤缺损。29例股前外侧皮瓣均成活，其中3例股前外侧皮瓣设计为3叶皮瓣，13例设计为双叶皮瓣，其他皮瓣未行分叶设计。25例存在口鼻瘘的患者中，11例应用股前外侧皮瓣进行封闭，其中7例术后行上颌赝复体修复；14例患者鼻腔侧未行封闭式修复，术后口鼻相通，其中6例行上颌赝复体修复。2例患者行种植体支持式义眼修复。术后随访4~88个月，11例患者因肿瘤复发或转移死亡，其余患者均无瘤生存。结论:口腔颌面肿瘤切除后复合眶内容物缺失的上颌骨缺损的修复重建中，股前外侧皮瓣因设计灵活，可行复杂缺损的修复，在封闭口鼻瘘、改善术后面型及口鼻腔卫生等方面具有显著优势，是理想的皮瓣。“,”Objective:To evaluate the use and effect of reconstruction with anterolateral thigh flap(ALTF)in orbitomaxillary defect resulting from oral maxillofacial oncology surgery.Methods:Patients with orbitomaxillary defects following enucleation of orbit were reconstructed with ALTF from January 2013 to September 2020 in Department of Oral & Maxillofacial Surgery-Head & Neck Oncology, Shanghai Ninth People’s Hospital and the data of the cases were collected. Based on the types of the defects, they were classified as orbit-nasal-oral defect, oronasal defect without defect of peri-orbit skin, nasal-orbit defect without defect of oral mucosa and peri-orbit skin defect. Based on the types of the defects and the number of the perforators of ALTF, the flaps were designed as tri-lobed, bi-lobed or mono-lobed flaps and oronasal fistula was determined to repair. Performance of maxillary prosthesis depended on the intraoral situation.Results:There were 19 male cases and 10 female cases and the age arranged from 23 to 82 years old. In terms of defect type, there were 8 cases of orbit-nasal-oral defect, 17 cases of oronasal defect without defect of peri-orbit skin, 1 case of nasal-orbit defect without defect of oral mucosa, 3 cases of peri-orbit skin defect. All the 29 cases of ALTF were successfully completed. Loculated flaps were designed in 16 cases, including 3 cases of tri-lobed flap and 13 cases of bi-lobed flaps. The oral-nasal fistula was repaired with ALTF in 11 cases and maxillary prosthesis was used in 7 cases after surgery. The oral-nasal fistula was not repaired in 14 cases and maxillary prosthesis was used in 6 cases in this group. Two cases were reconstructed with implant supported prosthesis with artificial eyes. The follow-up duration was 4 to 88 months. Eleven patients died of recurrence or metastasis and the other patients were alive without recurrence.Conclusions:In the reconstruction of the maxillary defects with intra-orbital loss following oromaxillofacial tumor resection, ALTF could be an ideal donor site because of flexible design, applicable in complicated defect repair and closure of oronasal fistula, improvement of facial appearance and sanitary maintenance of the oral and nasal cavities.