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L759是1975年9月在615近交系小鼠上开始建立的一个可移植性肉瘤白血病新瘤株,现已传至132代。其生长特性已基本稳定,在615系小鼠中用瘤细胞移植,发病率为100％,无自发缓解,平均存活时间13.8±2.5天;对不同年令、性别的615系小鼠和不同途径(包括口服)接种,均可发病。L759白血病细胞于局部皮下接种后迅速侵入血管并通过血行向全身播散,其特点是在接种局部可长出较大的实体瘤结,并逐渐发展为典型的白血病,故属肉瘤白血病。 L759与L615细胞形态相似。电镜观察在瘤细胞内看到池内A颗粒,在脾组织中还看到C型病毒样颗粒。 L759对抗癌药的敏感谱较广。不仅对抗代谢类及烷化刘类药物非常敏感,而且对生物碱类也颇敏感,长春新诚对瘤重的抑制率可以达到100％。对于L759的来源及其与L615的关系进行了讨论。
L759 is a new transplacental sarcoma leukemia cell line established in September 1975 in 615 inbred mice. It has been passed down to 132 generations. Its growth characteristics have been basically stable, with the tumor cell transplantation in 615-line mice, the incidence was 100%, no spontaneous remission, the average survival time of 13.8 ± 2.5 days; 615 chickens of different years, sex and different ways (Including oral) vaccination, can be disease. L759 leukemia cells rapidly invade the blood vessels and disseminate to the whole body through the blood lines after the local subcutaneous inoculation, which is characterized by the fact that larger solid tumor nodes can be grown locally in the inoculation and gradually develop into typical leukemia, so it is sarcoid leukemia. L759 and L615 cell morphology similar. Electron microscopy in the tumor cells to see the pool of A particles in the spleen also see the C-like virus-like particles. L759 anti-cancer drug sensitive spectrum is broader. Not only against the metabolism and alkylating Liu drugs are very sensitive, but also quite sensitive to alkaloids, Changchun Xin Cheng inhibition of tumor weight can reach 100%. The origin of L759 and its relationship with L615 are discussed.