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目的:研究HIF-1α、VEGF及其受体KDR和微血管密度(MVD)在子宫内膜癌组织中的表达及相互关系。方法:采用免疫组化法检测HIF-1α、VEGF、KDR在39例子宫内膜癌、18例子宫内膜不典型增生及17例正常子宫内膜组织中的表达状况,应用CD34标记MVD。结果:HIF-1α、VEGF、KDR、MVD在子宫内膜癌组织中呈高表达,显著高于子宫内膜不典型增生组织及正常子宫内膜组织,P值均<0.05,在子宫内膜癌组织中HIF-1α、VEGF、KDR的阳性表达率随肿瘤手术-病理分期期别的升高而增高,其中Ⅰ期与Ⅱ～Ⅳ期比较差异有统计学意义,P=0.0149。结论:HIF-1α、VEGF、KDR和MVD在正常子宫内膜、子宫内膜不典型增生及子宫内膜癌组织中的表达依次增高,提示HIF-1α、VEGF、KDR和MVD在子宫内膜癌发生发展中有重要作用,可将它们视为子宫内膜癌潜在侵袭性的肿瘤标志。
Objective: To study the expression of HIF-1α, VEGF and their receptors KDR and MVD in endometrial carcinoma and their correlation. Methods: Immunohistochemistry was used to detect the expression of HIF-1α, VEGF and KDR in 39 cases of endometrial carcinoma, 18 cases of endometrial dysplasia and 17 cases of normal endometrium. CD34-labeled MVD was used. Results: The expression of HIF-1α, VEGF, KDR and MVD in endometrial carcinoma was significantly higher than that in endometrial dysplasia and normal endometrium, both P <0.05. In endometrial carcinoma The positive expression rates of HIF-1α, VEGF and KDR in the tissues increased with the increase of tumor operation-pathological staging stage. The difference between stage Ⅰ and stage Ⅱ ~ Ⅳ was statistically significant (P = 0.0149). Conclusions: The expressions of HIF-1α, VEGF, KDR and MVD in normal endometrium, endometrial dysplasia and endometrial carcinoma increase in turn, suggesting that HIF-1α, VEGF, KDR and MVD in endometrial cancer Occurs in the development of an important role, they can be regarded as potentially invasive endometrial cancer tumor markers.