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目的:评价经肝动脉化疗栓塞术(TACE)联合激光热疗(LITT)治疗大鼠肝转移癌的疗效。方法:30只雄性WAG大鼠肝包膜下注入CC531结直肠癌肝转移癌细胞混悬液,种植术后13天行MRI检查,测量肿瘤体积V1,然后采取介入治疗措施:第14天时采取单纯TACE治疗(丝裂霉素(碘油(降解淀粉);②第14天时采取单纯LITT治疗(Nd:YAG激光);③联合TACE(第14天时)和LITT治疗(第21天时)。第28天时再次行MRI检查以确定肿瘤体积V2变化,比较肝肿瘤体积生长率V2/V1。结果:介入治疗后肿瘤体积与治疗前肿瘤体积之比分别为A组5.42、B组6.14、C组3.15。与对照组A组和B组相比,采取C组即TACE联合LITT的治疗方案明显抑制肝肿瘤的生长(Bonferroui检验,P<0.01)。结论:联合TACE和LITT的综合介入治疗方法与单纯TACE以及LITT相比,能明显抑制大鼠肝转移癌的生长。
Objective: To evaluate the efficacy of transcatheter arterial chemoembolization (TACE) combined with laser-thermostation (LITT) in the treatment of hepatic metastatic carcinoma in rats. METHODS: A total of 30 male WAG rats were injected subcutaneously into the liver with a subcutaneous injection of CC531 colorectal cancer metastatic cancer cell suspension. The MRI was performed 13 days after implantation to measure the tumor volume V1. Interventional treatment measures were then taken. TACE treatment (mitomycin C (lipodol) (degraded starch); 2 pure LITT treatment (Nd:YAG laser) on day 14; 3 combined TACE (day 14) and LITT treatment (day 21). Day 28 The MRI examination was performed again to determine the change in tumor volume V2, and to compare the volume growth rate of liver tumor V2/V1.Results: The ratio of tumor volume to tumor volume before treatment was 5.42 in group A, 6.14 in group B, and 3.15 in group C. Compared with control group A and B, treatment with CACE, ie TACE combined with LITT, significantly inhibited the growth of liver tumors (Bonferroui test, P<0.01).Conclusions: Combined TACE and LITT combined interventional therapy and TACE alone and LITT significantly inhibited the growth of rat liver metastases compared to LITT.