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研究应用稳定同位素~(15)N-甘氨酸和~(13)C-棕榈酸示踪测定全小肠切除术后患儿的肠吸收功能。方法:以 一例全小肠切除术后患儿作自身对照,两名健康儿童作正常对照,定期用~15N-甘氨酸示踪试验和~13C-棕榈酸呼气 试验来检测患儿残留消化道对氨基酸和脂肪酸的代偿吸收功能。结果:患儿在术后15月及24月对氨基酸的相对 吸收率分别为50%和52%,吸收高峰时间均在2.5~3.5h。对脂肪酸的相对吸收率则分别为57%和75%,吸收高峰 时间在3.5~4.5h。结论:用稳定同位素法测定肠吸收功能不仅安全、灵敏、特异性好,而且还反映肠吸收高峰时 间。根据本研究结果推断,结肠可能代偿吸收营养要素。
To study the intestinal absorption function of children after total small intestine resection with stable isotope ~ (15) N-glycine and ~ (13) C-palmitate. Methods: A case of total small bowel resection in children as a self-control, two healthy children as a normal control, regular use of ~ 15N-glycine tracer and ~ 13C-palmitate breath test to detect children with residual digestive tract amino acids And the compensatory absorption of fatty acids. Results: The relative absorption rates of amino acids in children after 15 months and 24 months were 50% and 52% respectively, and the peak absorption time was 2.5 ~ 3.5 hours. The relative absorption of fatty acids were 57% and 75%, respectively, and the peak absorption time was 3.5-4.5 h. Conclusion: The determination of intestinal absorption by stable isotope method is not only safe, sensitive and specific, but also reflects the peak time of intestinal absorption. According to the results of this study concluded that the colon may compensate for the absorption of nutrients.