AIM: To quantify the association between diabetes and glaucoma using Meta-analysis.METHODS: Pub Med and Embase were searched using medical subject headings and key words related to diabetes and glaucoma. The inclusion criteria were: 1) the study design was a prospective cohort study; 2) the exposure of interest was diabetes; 3) the outcome of interest was primary open angle glaucoma(POAG); 4) risk ratios(RR) and the corresponding 95% confidence interval(CI). Data were pooled using fixed effects models to take into account heterogeneity between studies. Seven prospective studies were selected. Diabetes increased the incidence of glaucoma by 36%(OR=1.36, 95% CI=1.25-1.50). There was no evidence of statistical heterogeneity(I~2=0, P=0.53) or publication bias(the funnel plot did not identify obvious asymmetry).RESULTS: Seven prospective cohort studies were incorporated in this Meta-analysis. The pooled RR of the association between POAG and diabetes based on the risk estimates of the seven cohort studies was 1.36(95% CI=1.24-1.50), with no significant heterogeneity across studies(I~2=0; P=0.526). The sensitivity analysis yielded a range of RRs from 1.34(95% CI=1.22-1.48) to1.40(95% CI=1.18-1.67).CONCLUSION: Diabetes is associated with a significantly increased risk of glaucoma. AIM: To quantify the association between diabetes and glaucoma using Meta-analysis. METHODS: Pub Med and Embase were searched using medical subject headings and key words related to diabetes and glaucoma. The inclusion criteria were: 1) the study design was a prospective cohort 3) the outcome of interest was primary open angle glaucoma (POAG); 4) risk ratios (RR) and the corresponding 95% confidence interval (CI). Data were pooled using fixed effects models to take into account heterogeneity between studies. Seven prospective studies were selected. Diabetes increased the incidence of glaucoma by 36% (OR = 1.36, 95% CI = 1.25-1.50). There was no evidence of statistical heterogeneity (I ~ 2 = 0, P = 0.53) or publication bias (the funnel plot did not identify obvious asymmetry) .RESULTS: Seven prospective cohort studies were incorporated in this Meta-analysis. The pooled RR of the association between POAG and diabetes based on the risk estimates of the seven The sensitivity analysis yielded a range of RRs from 1.34 (95% CI = 1.24-1.50) with no significant heterogeneity across studies (I~2 = 0; P = 0.526) ) to1.40 (95% CI = 1.18-1.67) .CONCLUSION: Diabetes is associated with a significantly increased risk of glaucoma.