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目的:探讨系统性红斑狼疮(SLE)患者抗ds-DNA抗体与全血细胞计数相关参数的关系。方法:回顾性选取SLE患者62例,同期健康体检者50例为研究对象。间接免疫荧光法测定抗ds-DNA抗体,全自动血液分析仪测定全血细胞计数,分析抗ds-DNA抗体与全血细胞计数各参数的相关性。结果:抗ds-DNA抗体阳性低滴度组和阴性组比较,白细胞计数及其分类计数降低;抗ds-DNA抗体阳性高滴度组比低滴度组大血小板比率和血小板体积分布宽度明显增加;红细胞分布宽度变异系数在抗ds-DNA抗体阴性组和阳性低滴度组之间,阳性低滴度组和高滴度组之间差异有统计学意义(P<0.05)。结论:外周全血细胞分析是监测SLE患者病情发展的简单实用检查,尤其红细胞分布宽度变异系数能全程反映SLE患者病情的变化。
Objective: To investigate the relationship between anti-dsDNA antibody and whole blood count in patients with systemic lupus erythematosus (SLE). Methods: Retrospectively selected 62 cases of SLE patients, 50 cases of healthy subjects over the same period as the research object. The anti-ds-DNA antibody was detected by indirect immunofluorescence assay. The whole blood count was determined by automatic hematology analyzer. The correlation between anti-dsDNA antibody and whole blood count was analyzed. Results: Compared with the negative group, the anti-ds-DNA antibody low titer group showed a lower leukocyte count and its differential count. The anti-dsDNA antibody positive high titer group had a significantly higher ratio of large platelet and platelet volume distribution than the low titer group The coefficient of variation of the distribution width of erythrocytes between the low-titer anti-dsDNA antibody group and the positive low titer group was significantly different between the positive low titer group and the high titer group (P <0.05). Conclusion: Peripheral blood cell analysis is a simple and practical test for monitoring the progression of SLE patients. In particular, the coefficient of variation of the distribution width of erythrocytes can fully reflect the changes of SLE patients.