目的　分析米非司酮配伍米索前列醇终止初孕 10～ 16周妊娠的安全性及有效性。方法　将 180例孕 10～ 16周要求药物终止妊娠的妇女分成 2组。实验组 :初孕者 94例 ;对照组 :经产者 86例。 2组均给米非司酮 75mg ,1次 /d ,连服 3d ,第 4d晨口服米索 0 6mg ,每 3～ 4h重复 1次 ,最多 3次。结果　 2组药流成功率分别为 90 4 %、93%。 2组用药无显著差异。结论　米非司酮配伍米索前列醇终止 10～ 16周妊娠成功率高 ,初孕经产同样有效 ,对初孕者是一种更安全、有效的流产方法 Objective To analyze the safety and efficacy of mifepristone and misoprostol in the termination of pregnancy of 10-16 weeks of first trimester. Methods 180 pregnant women who required termination of pregnancy for 10-16 weeks of pregnancy were divided into two groups. Experimental group: the first pregnancy 94 cases; control group: the production of 86 cases. 2 groups were given mifepristone 75mg, 1 / d, and even served 3d, morning 4d morning misoprostol 6mg, every 3 ~ 4h repeat 1, up to 3 times. Results The success rates of drug flow in two groups were 90 4% and 93% respectively. There was no significant difference between the two groups. Conclusion Mifepristone combined with misoprostol 10 to 16 weeks after the termination of high success rate of pregnancy, the first pregnancy through the same production effective, is a more safe and effective abortion method for the first trimester