高迁移率族蛋白B1(high mobility group box 1,HMGB1)为核内蛋白,具有高度保守性,表达于各种组织细胞胞核内,参与基因的转录、复制等,其被释放到胞核外则主要作为一种晚期炎症介质,介导炎症免疫应答.作为细胞应激的产物,HMGB1与包括病毒在内的病原体感染关系密切.近年来研究显示,HMGB1参与了多种病毒感染相关疾病的发生发展过程,该文就其研究进展作一综述.“,”High mobility group protein B1 (high mobility group box 1,HMGB1) is a nuclear protein that is highly conserved,constitutively expressed in various tissues and cells in the nucleus.It participates in gene transcription and replication,which is released into the nucleus mainly as a late cytokine mediated inflammatory immune response.As a result of cell stress,HMGB1 and pathogens including viruses infection are closely related.Recent studies have shown that HMGB1 is involved in the occurrence and development of many kinds of virus related diseases.This paper makes a review of the research progresses.