本文报告作者1983.6—1984.9用氨甲喋呤与5—氟脲嘧啶序贯疗法治疗29名晚期结直肠癌患者,取得了一定的疗效。 病例选择:结直肠癌经组织学证实并已有远外转移或局部病灶处于晚期已不能手术:有可测量的肿瘤,进行本治疗前至少一月未进行化疗或放射治疗;年龄在75岁以下;患者健康状况符合东部肿瘤协作组制定 This article reported that authors 1983.6-1984.9 treated with methotrexate and 5-fluorouracil sequential therapy in 29 patients with advanced colorectal cancer, achieved a certain effect. Case selection: Colorectal cancer was confirmed by histology and had distant metastases or localized lesions were in advanced stages. Surgery was not possible: there were measurable tumors. No chemotherapy or radiation therapy was performed at least 1 month prior to the treatment; age under 75 years. The patient’s health status was in accordance with the Eastern Oncology Group