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类固醇激素包括雌激素、雄激素和肾上腺皮质激素等是具有类固醇(甾体)基本结构的一类药物,均系亲脂疏水性化合物。与肽类激素不同,它们不是作用于细胞膜上的受体,而是直接进入细胞内,与细胞核受体结合而起作用。 一、类固醇激素受体与其受体后作用机制的基本概念 最初的假说是根据用放射性同位素标记的类固醇激素与靶细胞的胞浆和胞核提取物结合
Steroid hormones including estrogen, androgens and adrenocortical hormones are steroid (steroid) basic structure of a class of drugs, are lipophilic hydrophobic compounds. Unlike peptide hormones, they do not act on receptors on the cell membrane, but instead go directly into the cell and bind to the nuclear receptors. First, the basic concept of the steroid hormone receptor and its receptor after the mechanism of action The initial hypothesis is based on the combination of radioactive isotope labeled steroid hormone and the target cell cytoplasmic and nuclear extracts