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目的:观察“网脱Ⅰ号”口服液的急性毒性反应,为临床安全使用提供实验数据。方法:采用经典的急性毒性实验方法测定“网脱Ⅰ号”口服液的半数致死量(LD_(50))和最大给药量,观察其急性毒性症状,记录累积死亡数及小鼠体质量变化。结果:LD_(50)未测出,小鼠最大给药量为150g·kg~(-1)·d~(-1),相当于成人日剂量的140倍。结论:“网脱Ⅰ号”口服液无明显毒性反应,是安全可靠的。
OBJECTIVE: To observe the acute toxicity of “net off I ” oral solution to provide experimental data for clinical safe use. Methods: The classic acute toxicity test method was used to determine the LD 50 and the maximum dose of “Wangdu I” oral solution. The acute toxicity symptoms were observed and the cumulative number of death and the number of mice were recorded Quality changes. Results: LD_ (50) was not detected, the maximum dose of 150g · kg -1 · d -1 in mice was equivalent to 140 times of the adult daily dose. Conclusion: “net off Ⅰ ” oral solution without significant toxicity, is safe and reliable.