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目的:观察加味苓甘五味姜辛半夏汤治疗婴幼儿哮喘的有效性和安全性及其对患儿肺功能与Clara细胞分泌蛋白的影响。方法:将90例哮喘患儿随机分为两组,治疗组45例予以加味苓甘五味姜辛半夏汤治疗,对照组45例予以雾化吸入布地奈德、复方异丙托溴铵联合抗感染治疗。两组均治疗5d后观察疗效。结果:愈显率治疗组为82.22%,对照组为55.56%,组间比较,差异有统计学意义(P<0.01);在缓解咳嗽、喘息、肺部哮鸣音方面两组差异无统计学意义(P>0.05),但两组喉中痰鸣与肺部痰鸣音改善比较,差异有统计学意义(P<0.01);且治疗组在Clara细胞分泌蛋白调节、2周后复查肺功能FEV1%和PEF%方面,较对照组均有明显改善(P<0.05)。结论:加味苓甘五味姜辛半夏汤治疗婴幼儿哮喘安全有效,可能系通过内源性兔疫调节,获得温肺化痰、降逆平喘之功效。
OBJECTIVE: To observe the efficacy and safety of Jia Ling Banxia Decoction for treating children with asthma and its effect on lung function and Clara cell secretory protein in children. Methods: Ninety children with asthma were randomly divided into two groups. The treatment group was treated with Ling-ling five-flavored Jiangxin Banxia Decoction, and the control group with inhaled budesonide. The combination of ipratropium bromide Infection treatment. Both groups were treated for 5 days after treatment. Results: The cure rate was 82.22% in the treatment group and 55.56% in the control group, with significant difference between the two groups (P <0.01). There was no significant difference between the two groups in relieving cough, wheezing and lung wheezing (P> 0.05). However, there was significant difference between the two groups in the improvement of phlegm and throat sputum (P <0.01). In the treatment group, the protein secreted by Clara cells was adjusted and lung function was examined after 2 weeks FEV1% and PEF%, compared with the control group were significantly improved (P <0.05). Conclusion: Modified Ling Gan Wu Wei Jiang Xin Banxia Decoction safe and effective treatment of infant asthma, may be through endogenous control of tussah disease, access to phlegm, down anti-asthma effect.