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目的 研究饮酒习惯对丙型肝炎病毒(HCV)感染者慢性 化的影响。方法 我们收集142例HCV感染者的资料，以病程＞6 个月，白蛋白/球蛋白＜1.5和/或ALT＞40U者、或临床确诊为慢性丙型肝炎(HC)的患者 ，分入病例组，共76例；凡抗-HCV(+)或/和HCV RNA(+)持续6个月以上不符合慢性丙型肝炎 条件者为对照组，共66例。结果 病例组有饮酒习惯的比例明显高于 对 照组(χ2=8.75，P＜0.003，OR=2.79)，经性别分层分析：男性OR=2.65，女性OR =4.29，OR总=3.30，提示女性HCV感染者饮酒较男性更易发展成慢性肝病；饮酒量＜100 ml/次、OR=3.18，＞300ml/次、OR=5.45，饮酒量与慢性丙型肝炎呈相关关系；持续饮酒 ≤ 5年、OR=1.74，6～15年、OR=3.51，＞15年，OR=5.10，饮酒年限越长，其慢性化的危险 性越大。结论 (1)饮酒可能是导致HCV感染慢性化的重要危险因素；(2 )积极开展健康教育，提高人们的自我保健意识，规劝HCV感染者戒酒可能是预防HCV感染者 慢性化的重要措施之一。
Objective To study the influence of drinking habits on the chronicity of hepatitis C virus (HCV) infection. Methods We collected data from 142 HCV-infected patients and classified them into patients with a duration of> 6 months, albumin / globulin <1.5 and / or ALT> 40U, or clinically diagnosed as chronic hepatitis C (HC) Group, a total of 76 cases; Where anti-HCV (+) or / and HCV RNA (+) for 6 months or more do not meet the conditions of chronic hepatitis C as control group, a total of 66 cases. Results The proportion of drinking habits in the case group was significantly higher than that of the control group (χ2 = 8.75, P <0.003, OR = 2.79). According to gender stratification analysis, the OR of male was 2.65, OR was 4.29, OR was 3.30, The results showed that women with HCV infection developed more chronic liver disease than men. Alcohol consumption was <100 ml / time, OR = 3.18,> 300ml / time, OR = 5.45. Alcohol consumption was related to chronic hepatitis C Year, OR = 1.74,6 ~ 15 years, OR = 3.51,> 15 years, OR = 5.10, the longer the drinking period, the greater the risk of chronic. Conclusions (1) Alcohol consumption may be an important risk factor leading to the chronicity of HCV infection. (2) Actively carry out health education to improve people’s awareness of self-care, and to persuade people with HCV infection to stop drinking may be an important measure to prevent chronic HCV infection one.