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评价左氧氟沙星治疗伤寒的临床疗效和体外抗菌活性。方法:以国产和进口左氧氟沙星片剂做随机对照试验治疗急性伤寒共30例,用药量均为200mg,每日2次,疗程7d。结果:两种药物均获得了良好的临床疗效,临床治愈率和细菌清除率均为100%,国产和进口左氧氟沙星在临床疗效和细菌学疗效方面均无差异(P>0.05),两种药对伤寒杆菌的MIC90均为0.125mgL。全部病例未见明显不良反应发生。结论:左氧氟沙星治疗伤寒临床疗效好,抗菌活性高,安全可靠。国产左氧氟沙星的疗效和进口产品相同。
To evaluate the clinical efficacy and in vitro antibacterial activity of levofloxacin in the treatment of typhoid fever. Methods: Randomized controlled trials of domestic and imported levofloxacin tablets were used to treat 30 cases of acute typhoid fever. The dosage was 200mg twice daily for 7 days. Results: Both drugs had good clinical curative effect. The clinical cure rate and bacterial clearance rate were both 100%. There was no difference between domestic and imported levofloxacin in clinical efficacy and bacteriological efficacy (P> 0.05) Salmonella typhimurium MIC90 are 0.125mgL. No adverse reactions occurred in all cases. Conclusion: Levofloxacin is effective and safe in the treatment of typhoid fever. The efficacy of domestic levofloxacin and imported products the same.