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游离阻断14例中、晚期肺癌病人的单侧肺(或肺叶)主要血管,经肺动脉、肺静脉插管与心泵连接,建立与体循环隔离的体外肺循环。在肝素化预充液中加入超量表阿霉素和环磷酰胺,进行高温(41~43℃)灌注50~60分钟,停机关胸。本组无手术死亡。术后1、2年分别死亡2、5例,生存率分别为85.7%和50%,余7例均健在。术后10~12个月对肺部残存肿块在CT定向下穿刺活检均为纤维组织。证明此疗法杀灭肿瘤组织效果确切,对正常肺组织的损伤是轻微且可逆的
Freely block the main blood vessels of unilateral lung (or lobe) in 14 patients with advanced and advanced lung cancer. The pulmonary artery and pulmonary vein were intubated and connected with the heart pump to establish an extracorporeal pulmonary circulation isolated from the systemic circulation. In the heparinized priming solution, excess epirubicin and cyclophosphamide were added, and perfusion was performed at a high temperature (41-43°C) for 50-60 minutes, and the organ was stopped. There were no operative deaths in this group. Two and five patients died in the 1st and 2nd year after surgery. The survival rates were 85.7% and 50%, respectively. The remaining 7 patients were all healthy. Ten to twelve months postoperatively, all lung biopsy under CT-directed biopsy was fibrous tissue. It is proved that this therapy is effective in killing tumor tissue, and damage to normal lung tissue is slight and reversible