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目的:观察糖肾Ⅰ号方对早期糖尿病肾病大鼠的疗效。方法:通过单侧肾切除合并注射链脲佐菌素(STZ)建立早期糖尿病肾病大鼠模型,随机分为假手术组(SO)、模型对照组(M)、糖肾Ⅰ号组(TS)、洛汀新组(B),每组10只。模型成功后给予不同的干预共8周,末次给药12h后,采集尿液、血液标本,观察各组大鼠的一般状况、肾重、肾重指数、血糖、肾功(Scr、BUN)等指标的变化。结果:与模型组比较,糖肾Ⅰ号治疗组肾重、血糖明显下降(P<0.01),血清Scr、BUN显著降低(P<0.01)。与洛汀新组比较,各项指标无明显差异。结论:糖肾Ⅰ号可改善DN大鼠的营养状况,增加其体重,抑制肾脏肥大,降低血糖,改善肾功能,治疗效果确切。
Objective: To observe the effect of Tangshen No.1 on early diabetic nephropathy rats. Methods: A rat model of early diabetic nephropathy was established by unilateral nephrectomy combined with streptozotocin (STZ) and randomly divided into sham operation group (SO), model control group (M), Tangshen Ⅰ group (TS) , Lotensin group (B), each group of 10. The model was given different intervention after a total of 8 weeks. After the last administration, urine and blood samples were collected to observe the general condition, kidney weight, kidney index, blood glucose, renal function (Scr, BUN) Changes in indicators. Results: Compared with the model group, the renal weight and blood glucose in the Tangshen Ⅰ treatment group were significantly decreased (P <0.01), and the levels of Scr and BUN in the serum were significantly decreased (P <0.01). Compared with Lotensin new group, there was no significant difference between the indexes. Conclusion: Tangshen Ⅰ can improve the nutritional status of DN rats, increase its body weight, inhibit renal hypertrophy, lower blood sugar, improve renal function, the exact effect.