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目的:探讨叉头样转录因子O4(FOXO4)在大肠癌组织中的表达及其临床意义。方法:选取80例大肠癌患者手术切除肿瘤及其癌旁组织标本(TNM分期:I期18例,Ⅱ期32例,Ⅲ期24例,Ⅳ期6例),应用免疫组织化学染色方法检测FOXO4在大肠癌和癌旁组织的表达情况,并分析其与患者临床病理特征的关系。结果:FOXO4在大肠癌组织中的阳性表达率为47.50%(38/80),明显低于在癌旁组织91.25%(73/80)的表达率(P<0.01)。在肿瘤组织中FOXO4表达水平在患者年龄、性别,肿瘤大小和侵润深度之间的差异无统计学意义(P>0.05);但与肿瘤分化程度、分期和淋巴结转移之间差异有统计学意义(P<0.05)。结论:FOXO4在大肠癌中表达明显降低或缺失,提示其可能在大肠癌的发生、发展过程中起抑癌基因的作用。
Objective: To investigate the expression of forkhead-like transcription factor O4 (FOXO4) in colorectal carcinoma and its clinical significance. Methods: 80 cases of colorectal cancer were selected for surgical resection of tumor and its adjacent tissues (TNM stage: 18 cases in stage I, 32 cases in stage Ⅱ, 24 cases in stage Ⅲ and 6 cases in stage Ⅳ). Immunohistochemical staining was used to detect FOXO4 In colorectal cancer and paracancerous tissue, and to analyze its relationship with clinicopathological features. Results: The positive expression rate of FOXO4 in colorectal carcinoma was 47.50% (38/80), which was significantly lower than that in adjacent tissues (91.25%, 73/80) (P <0.01). There was no significant difference in the expression level of FOXO4 between tumor patients in age, sex, tumor size and depth of invasion (P> 0.05), but there was a significant difference between the expression of FOXO4 and the degree of tumor differentiation, stage and lymph node metastasis (P <0.05). Conclusion: FOXO4 is significantly decreased or absent in colorectal cancer, suggesting that FOXO4 may play a role in tumorigenesis and progression of colorectal cancer.