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盐酸戊乙奎醚是我国自主研发的一类抗胆碱新药,具有多方面药理作用,如戒毒、离体子宫松弛、肝损伤保护作用、肾损伤保护作用、前脑缺血再灌注损伤的保护作用,同时其临床应用也较多,用于胃肠道疾病、眼科疾病、呼吸道疾病、中枢神经系统疾病、麻醉、泌尿生殖道疾病、肾绞痛及膀胱刺激症、抗感染性休克、抗胆绞痛等。文中就其药动学研究做一综述,包括其拆分研究、动物体内的药动学、动物体内的分布、人体内的药动学,为其进一步开发提供参考。
Penehyclidine hydrochloride is a kind of anticholinergic drug developed independently in our country. It has many pharmacological effects such as detoxification, isolated uterine relaxation, protection of liver injury, protection of renal injury, protection of forebrain ischemia-reperfusion injury Role, and more clinical applications, for gastrointestinal diseases, ophthalmic diseases, respiratory diseases, central nervous system diseases, anesthesia, genitourinary diseases, renal colic and bladder irritation, anti-septic shock, anti-gallbladder Colic and so on. In this paper, a review is made on its pharmacokinetic studies, including its resolution studies, pharmacokinetics in animals, distribution in animals and pharmacokinetics in humans, providing reference for its further development.