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手足口病(hand-foot-mouth disease,HFMD)是严重威胁儿童健康的全球性传染病~[1],引起该病的病原主要是柯萨奇病毒A组16型(Cox A16)和肠道病毒71型(EV71)~[2]。其中EV71感染致残及病死率较高~[3]。自1969年起全世界很多国家和地区相继出现了EV71的流行报道。1987年,中国大陆首次发现EV71感染,1995年国内首次分离出EV71病毒~[4]。20世纪90年代以来,EV71的流行在亚太地区呈上升趋势,已越来越受到人们的重视~[5]。
Hand-foot-mouth disease (HFMD) is a global epidemic that is a serious threat to children’s health. [1] The pathogens causing this disease are mainly Cox A16 and intestinal Virus 71 (EV71) ~ [2]. Which EV71 infection disability and high mortality ~ [3]. Since 1969 in many countries and regions around the world have been the EV71 popular reports. In 1987, EV71 infection was first detected in mainland China. In 1995, EV71 virus was isolated for the first time in China [4]. Since the 90s of the 20th century, the prevalence of EV71 has been on the rise in the Asia Pacific region and it has received more and more attention [5].