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建立荷肝癌裸鼠动物模型。治疗组在肿瘤组织内植入125碘(125I)粒子,对照组不进行任何干预。治疗21d后测量各组肿瘤体积并计算抑瘤率,切除肿瘤组织进行常规病理检查。结果治疗组和对照组平均肿瘤体积分别为(601.5±154.1)mm3和(1182.9±296.6)mm3,差异有显著性(P<0.01);治疗组抑瘤率为49.2%。治疗组病理切片显示靠近125I粒子处肿瘤细胞坏死,但远离粒子处仍可见大量存活肿瘤细胞。对照组肿瘤细胞生长良好。表明125I粒子肿瘤组织内植入可抑制荷肝癌裸鼠肿瘤生长,杀死局部肿瘤细胞,但该粒子杀伤距离有限。
Establishment of liver cancer nude mice model. The treatment group implanted 125 I (125 I) particles in the tumor tissue without any intervention in the control group. After 21 days of treatment, the tumor volume of each group was measured and the tumor inhibition rate was calculated. The tumor tissues were removed for routine pathological examination. Results The average tumor volume in the treatment group and the control group were (601.5 ± 154.1) mm3 and (1182.9 ± 296.6) mm3, respectively, with significant difference (P <0.01). The tumor inhibition rate in the treatment group was 49.2%. The pathological sections of the treatment group showed that the tumor cells near 125I particles were necrosis, but a large number of surviving tumor cells were still visible away from the particles. Tumor cells in the control group grew well. It is indicated that 125I particle tumor tissue can inhibit tumor growth in nude mice bearing liver cancer and kill local tumor cells, but the particle has a limited killing effect.