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目的探讨急性心肌梗死(AMI)患者血尿酸水平与心肌梗死预后的关系。方法比较849例AMI患者入院时血尿酸水平在性别、年龄、入院心功能分级(Killip分级)组间的差异。分析未调整和经多因素调整的入院血尿酸水平对AMI患者出院心功能≥3级和住院期间死亡的危险度。结果在性别、年龄、入院心功能分级组AMI患者血尿酸水平均有显著差异(均P<0.01)。经多因素调整后显示入院时血尿酸水平升高会增加患者住院期间不良结局的风险(出院时心功能≥3级和住院期间死亡的OR值分别为1.004,1.006)。结论入院时血尿酸升高可能是心肌梗死急性期发生心力衰竭及死亡的独立危险因素。
Objective To investigate the relationship between serum uric acid level and the prognosis of myocardial infarction in patients with acute myocardial infarction (AMI). Methods 849 patients with AMI admitted to hospital blood uric acid levels in gender, age, admission cardiac function classification (Killip classification) differences between groups. Analysis of unadjusted and multivariate adjusted blood levels of uric acid on AMI patients discharged at cardiac function ≥ grade 3 and in-hospital mortality risk. Results There were significant differences in serum uric acid levels between AMI patients of gender, age and admission grade (all P <0.01). Multivariate adjustment showed that elevated serum uric acid levels at admission increased the risk of adverse outcomes during hospitalization (OR = ≥3 for hospital discharge and 1.004, 1.006 for death during hospitalization). Conclusion The elevated serum uric acid may be an independent risk factor for heart failure and death in the acute stage of myocardial infarction.