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心血管疾病是导致人类死亡的主要原因之一,动脉粥样硬化(Atherosclerosis,As)是心血管疾病的重要病理基础,炎症反应是动脉粥样硬化的重要病理机制。脂代谢紊乱是动脉粥样硬化的独立危险因素,贯穿动脉粥样硬化的始终,并且是导致炎症反应发生的重要原因。DNA甲基化是一种不改变基因核苷酸序列而能调控基因表达的一种重要的表观遗传学方式。有研究证明,脂代谢紊乱的发生、发展与DNA甲基化存在密切关系。本文将围绕与脂代谢紊乱相关基因对动脉粥样硬化过程中脂代谢紊乱与DNA甲基化的关系做一综述。
Cardiovascular disease is one of the major causes of human death. Atherosclerosis (As) is an important pathological basis of cardiovascular diseases. Inflammatory reaction is an important pathological mechanism of atherosclerosis. Disturbance of lipid metabolism is an independent risk factor for atherosclerosis, which persists throughout atherosclerosis and is an important cause of inflammation. DNA methylation is an important epigenetic approach that regulates gene expression without changing the nucleotide sequence of a gene. Studies have shown that the occurrence and development of lipid metabolism disorders and DNA methylation are closely related. This review focuses on the relationship between genes associated with dyslipidemia and disorders of lipid metabolism and DNA methylation during atherosclerosis.