本实验研究了5只猫蜗外电极慢性植入和电刺激引起的耳蜗组织病理学改变。刺激电极球分别固定在圆窗和鼓岬上,用双相平衡的0.4～1.8mA、脉宽100μS电脉冲作1276～1526h的慢性电刺激。光学显微镜检查耳蜗组织病理学改变发现:圆窗和鼓岬电极固定良好;除1耳电极推压圆窗膜与Hook区骨螺旋板粘连外,电极固定部位的圆窗膜均增厚;刺激侧与对照侧耳蜗下基底转内可见不同程度外毛细胞损失、轻度内毛细胞损失和小范围Corti’s结构消失;2个刺激侧耳蜗近圆窗2%基底膜长度范围内少量螺旋神经节细胞损失。提示蜗外电极行电刺激虽比蜗内电极安全,但在耳蜗下基底转仍有轻度组织病理学改变. In this study, we investigated the histopathological changes of the cochlea caused by chronic implants and electrical stimulation in five cats. Stimulation of the electrode ball were fixed in the round window and promontory promontory, with biphasic balanced 0.4 ~ 1.8mA, pulse width 100μS electric pulse for 1276 ~ 1526h of chronic electrical stimulation. Optical microscope examination of cochlear histopathology found that the round window and the promontory promontory were well fixed. The round window film of the fixed part of the electrode was thickened except for the attachment of the round window membrane of the 1-ear electrode to the bone spiral plate of the Hook region. In the control group, the loss of outer hair cells, mild loss of inner hair cells and the disappearance of Corti’s structure were seen in the basilar turn of the control cochlea. A small amount of spiral ganglion cells were lost in 2% . It is suggested that although the electrical stimulation of the cochlear electrode is more safe than the electrode in the cochlear electrode, mild histopathological changes still exist in the basement of the cochlea.