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甲型流感病毒有两种主要的表面糖蛋白:血凝素(HA)和神经氨酸酶(NA)。NA诱导产生的抗NA特异性抗体无中和能力,但能使病毒的复制降低到致病性阈值以下,从而能预防人与小鼠发病。本文作者对野型流感病毒(A/Udorn/72)纯化的N2-NA及由杆状病毒重组体在昆虫中产生的N2-NA的免疫原性进行了比较。
Influenza A virus has two major surface glycoproteins: hemagglutinin (HA) and neuraminidase (NA). NA-induced anti-NA specific antibodies have no neutralizing ability, but can reduce the replication of the virus below the pathogenicity threshold, thereby preventing the onset of human and mouse. The authors compared the immunogenicity of N2-NA purified by wild-type influenza virus (A / Udorn / 72) and N2-NA produced by the baculovirus recombinant in insects.