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本文对23例恶性纤维组织细胞瘤((MFH)及19例其他软组织肿瘤的免疫组化研究表明,AACT,AAT阳性率最高,是肿瘤性组织细胞的良好标志物,对MFH有一定诊断价值。Lys不是恶性组织细胞的良好标志物。Des的表达提示部分肿瘤细胞向肌纤维母细胞分化,Vim的表达则提示向纤维母细胞分化。所以,我们的研究结果表明MFH可能来自未分化间叶细胞,并在不同情况下向组织细胞、纤维母细胞和肌纤维母细胞等不同方向分化,而表现出复杂的组织学形态。
In this paper, immunohistochemical studies of 23 cases of malignant fibrous histiocytoma (MFH) and 19 other soft-tissue tumors showed that AACT and AAT were the most positive markers, and they were good markers for tumor-tissue cells. They have a certain diagnostic value for MFH. Lys is not a good marker of malignant tissue cells.Des expression suggests that some tumor cells differentiate into myofibroblasts, and Vim’s expression suggests differentiation into fibroblasts. Therefore, our results suggest that MFH may be derived from undifferentiated mesenchymal cells. In different situations, it differentiates into histiocytes, fibroblasts and myofibroblasts in different directions, and shows a complex histological morphology.