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细胞骨架是由微丝、微管和中间纤维等组成的纤维状聚合物和各种调控蛋白交错连接的网络结构,分别与细胞膜上的特殊结构(如黏附斑、细胞间连接等)相互联系,并与细胞核的支架系统相互作用。在不同力的作用下,细胞发生不同的形变,继而引起不同的细胞骨架组分的重装,表现出不同的细胞反应,在真核细胞内对维持细胞形态、细胞内运输、变形运动、细胞分化及受体介导的信号转导等方面发挥着重要作用。细胞骨架参与的各种生理活动常与其动态变化紧密相连。
Cytoskeleton is a network structure composed of fibrillar polymers composed of microfilaments, microtubules and intermediate fibers, and various regulatory proteins, which are interconnected with special structures (such as adhesion spots and intercellular junctions) on the cell membrane, respectively. And interact with the scaffold system of the nucleus. Under the action of different forces, the cells undergo different deformations, which in turn cause reassembly of different cytoskeletal components and show different cellular responses. In eukaryotic cells, cell morphology, intracellular transport, deformational motility, Differentiation and receptor-mediated signal transduction play an important role. Cytoskeleton involved in a variety of physiological activities and its dynamic changes are often closely linked.