对３例胃肠道多发性淋巴瘤性息肉（ＭＬＰ）病例进行组织学及免疫组织化学分析。１例肿瘤细胞为中等大小，胞浆淡且透明伴显著核分裂，ＬＮ１染色显示胞浆内点状阳性，可见典型的上皮区域浸润象（ＬＥＬ），推测其来源于ｍａｒｇｉｎａｌｚｏｎｅｃｅｌｌ（ＭＺＣ），为ｍｕｃｏｓａ－ａｓｓｏｃｉａｔｅｄｌｙｍｐｈｏｉｄｔｉｓｓｕｅ（ＭＡＬＴ）淋巴瘤。２例肿瘤细胞中等大小，核近似圆形伴轻度陷凹，ＬＮ１染色肿瘤细胞阴性，ＬＮ２染色细胞核膜强阳性，未见ＬＥＬ，推测其来源于僧帽带细胞（ＭＣ）。本研究证明了ＭＬＰ除可为多中心起源的ＭＣ来源外，也可是ＭＺＣ来源的ＭＡＬＴ淋巴瘤晚期扩散的结果。 Histological and immunohistochemical analysis of 3 cases of multiple lymphoma polyposis (MLP) in the gastrointestinal tract were performed. In 1 case, the tumor cells were medium in size, and the cytoplasm was light and transparent with significant mitosis. LN1 staining showed positive dot-like in cytoplasm and typical epithelial infiltrates (LEL), presumably originating from marginal zone cells (MZC) and being mucosa- Associatedmphoidtissue (MALT) lymphoma. In 2 cases, the tumor cells were of medium size, the nucleus was nearly round with mild depression, LN1 stained tumor cells were negative, LN2 stained nuclear membranes were strongly positive, and no LEL was seen, presumably originating from the cap-band cells (MC). This study demonstrates that MLP can be a multi-center origin of MC origin, but can also be the result of MZC-derived late spread of MALT lymphoma.