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近年来尘肺合并肺癌的报道增多,矽尘与肺癌有无关系?已成为医学界关注的问题。各国学者从动物试验、临床观察及流行病学等方面进行了大量研究,但结果尚有争议。本文仅就近年来有关游离二氧化硅的致癌作用、致癌机理、矽肺与肺癌关系的研究以及存在问题作一简单叙述。 一、游离二氧化硅致癌作用的实验研究 Wanger在1972年用悬浮在盐水内的游离二氧化硅对Wisfer大鼠胸膜注射,结果1/3的大鼠产生恶性淋巴瘤,另有3只出现增生性淋巴瘤。1980年他又发现游离二氧化硅所致的肿瘤,其性质与大鼠品种有关,如Alderly Park鼠的遗传性能明显大于Agus大鼠。此后不少学者进一步采用不同结晶形态的游离二氧化硅、不同品系的动物,从不同
In recent years, reports of pneumoconiosis with increased lung cancer, silica dust and lung cancer has become the concern of the medical profession. A great deal of research has been carried out in animal experiments, clinical observation and epidemiology in various countries, but the results are still controversial. This article only on the recent years, the carcinogenic effect of free silica, carcinogenic mechanism, the relationship between silicosis and lung cancer research and existing problems for a brief account. An Experimental Study on the Carcinogenicity of Free Silica Wanger injected the pleural membrane of Wisfer rats with free silica suspended in saline in 1972. One third of the rats developed malignant lymphoma and another 3 developed hyperplasia Sexual lymphoma. In 1980 he also found that free silica-induced tumors, the nature and rat varieties, such as Alderly Park mice significantly higher genetic performance than Agus rats. Since then, many scholars further use different crystalline forms of free silica, different strains of animals, from different