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作者从1970～1990年加拿大Kingston综合医院治疗的706例乳癌病例中,选择329例进行研究,术前经临床、放射学和同位素扫描等检查确诊无远处转移,局部病灶不大,无皮肤或胸壁浸润,炎性癌以及乳腺切除标本边缘阳性者则不包括在内。全组均做了全乳腺切除术,309例(94%)同时还清除了胶淋巴结。术后胸壁均未行放射治疗。43例绝经前妇女伴腋淋巴结阳性者均进行环磷酰胺、氨甲嘌吟和氟尿嘧啶辅佐化疗,13例绝经后妇女伴淋巴结阳性和肿瘤雌激素受
The authors selected 329 out of 706 cases of breast cancer treated at the Kingston General Hospital in Canada from 1970 to 1990. They were selected for clinical study, radiology, and isotope scans. No distant metastases were diagnosed before surgery. Chest wall infiltration, inflammatory cancer, and mammectomy specimen marginal positives were not included. Full mastectomy was performed in all groups. 309 patients (94%) also had axillary lymph nodes removed. No postoperative radiotherapy was performed on the chest wall. Forty-three cases of premenopausal women with axillary lymph node positive were treated with cyclophosphamide, methotrexate and fluorouracil adjuvant chemotherapy, and 13 cases of postmenopausal women with lymph node positive and tumor estrogen were affected.