Objective: To evaluate the effect of a modified cystectomy in the preservation of erectile and ejaculatory functions in men with non malignant bladder diseases. Methods: Seven cases with average age of 27 years presented with bladder diseases necessitating cystectomy, including 2 tuberculous contractile bladder, 1 extensive polypoid cystitis glandularis and 4 late stage neurogenic bladder. We performed a modified simple cystectomy reserving both vasa deferentia, seminal vesicles, prostate and neurovascular bundles with the construction of an Indiana pouch or ileal neobladder. Results: The average operation time was 5 h 45 min. There were no perioperative complications. With a follow-up of 9months to 60 months, the erectile and ejaculatory functions were normal in all the cases. All patients remained completely continent without dysuria. The upper urinary tract was in good condition 3 and 24 months after operation. Conclusion: Modified cystectomy with preservation of the vasa deferentia, seminal vesicles, Objective: To evaluate the effect of a modified cystectomy in the preservation of erectile and ejaculatory functions in men with non malignant bladder diseases. Methods: Seven cases with average age of 27 years presented with bladder diseases necessitating cystectomy, including 2 tuberculous contractile bladder, 1 extensive polypoid cystitis glandularis and 4 late stage neurogenic bladder. We performed a modified simple cystectomy for both vasa deferentia, seminal vesicles, prostate and neurovascular bundles with the construction of an Indiana pouch or ileal neobladder. Results: The average operation time was 5 h 45 There was no perioperative complications. With a follow-up of 9 months to 60 months, the erectile and ejaculatory functions were normal in all the cases. All patients remained completely continent without dysuria. The upper urinary tract was in good condition 3 and 24 months after operation. Conclusion: Modified cystectomy with preservation of the vasa deferentia , seminal vesicles,