1例45岁女性患者因甲状腺功能亢进症口服甲巯咪唑和丙硫氧嘧啶，2周后因诱发粒细胞缺乏症停药。约1个月后遵医嘱再次服用甲硫咪唑10 mg、3次/d，分别于第1次服药后约2 h、第2次用药后约0.5 h出现高热、寒战，最高体温39.5 ℃。实验室检查示血白细胞计数5.99×10n 9/L，中性粒细胞0.91，C反应蛋白2.3 mg/L，细菌血培养阴性。考虑为甲巯咪唑引起的药物热，停用该药并予对症治疗，4.5 h后患者体温降至36.5 ℃。随访1年，患者未再服用甲巯咪唑，未再出现高热、寒战症状。n “,”A 45-year-old female patient received oral methimazole and propylthiouracil for hyperthyroidism. The drug was discontinued 2 weeks later due to methimazole-induced agranulocytosis. About 1 month later, the patient was re-given methimazole 10 mg thrice daily according to the doctor′s instructions and advice. She developed high fever and chills about 2 hours after the first administration and half on after the second administration, respectively, with a maximum body temperature of 39.5 ℃. The laboratory tests showed WBC 5.99×10n 9/L, neutrophil 0.91, C-reactive protein 2.3 mg/L, and negative bacterial blood culture. Drug fever caused by methimazole was considered. Methimazole was stopped and symptomatic treatment was given. Four and a half hours later, the patient′s body temperature dropped to 36.5 ℃. At 1 year of follow-up, the patient did not take methimazole again, and neither high fever nor chills recurred.n