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目的探讨阿托伐他汀对特发性扩张型心肌病(IDCM)伴心力衰竭患者心功能的影响。方法选择2014年6月—2016年2月无锡市人民医院心血管内科收治的IDCM伴心力衰竭患者96例,随机分为对照组和观察组,每组48例。对照组患者给予常规药物治疗,观察组患者在对照组基础上给予阿托伐他汀;两组患者均连续治疗12个月。比较两组患者治疗前后血清C反应蛋白(CRP)水平、左室射血分数(LVEF)、左心室舒张期末内径(LVEDD)、左心室缩短速率(FS)、血清总胆固醇(TC)及低密度脂蛋白(LDL)水平。结果两组患者治疗前血清CRP水平、LVEF、LVEDD、FS、血清TC及LDL水平比较,差异无统计学意义(P>0.05);观察组患者治疗后血清CRP水平、LVEDD、FS、血清TC及LDL水平低于对照组,LVEF高于对照组(P<0.05)。结论阿托伐他汀可有效改善IDCM伴心力衰竭患者心功能。
Objective To investigate the effect of atorvastatin on cardiac function in patients with idiopathic dilated cardiomyopathy (IDCM) complicated with heart failure. Methods Ninety-six IDCM patients with heart failure admitted to Department of Cardiology, Wuxi People’s Hospital from June 2014 to February 2016 were randomly divided into control group and observation group, with 48 cases in each group. Patients in the control group were given conventional drug therapy. Patients in the observation group were given atorvastatin on the basis of the control group. Patients in both groups were treated continuously for 12 months. The levels of serum C-reactive protein (CRP), left ventricular ejection fraction (LVEF), left ventricular end diastolic dimension (LVEDD), left ventricular shortening (FS), total cholesterol (TC) and low density Lipoprotein (LDL) levels. Results There was no significant difference in serum CRP level, LVEF, LVEDD, FS, serum TC and LDL levels between the two groups before treatment (P> 0.05). The levels of serum CRP, LVEDD, FS, LDL level was lower than that of control group, LVEF was higher than that of control group (P <0.05). Conclusions Atorvastatin can effectively improve cardiac function in IDCM patients with heart failure.