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目的:探讨人类DNA修复基因XRCC1 Arg194Trp单核苷酸多态性与内蒙古人群患肾癌易感性的关系。方法:采用聚合酶链反应-限制性片段长度多态性的方法检测76例肾癌患者及82例正常人群基因XRCC1 194的多态性。分析各基因型与肾癌发生的关系。结果:研究结果显示XRCC1194肾癌组基因型分布频率为Arg/Arg50%、Arg/Trp 38%、Trp/Trp12%,健康对照组为Arg/Arg 56%、Arg/Trp34%、Trp/Trp10%、两组之间无差异(P>0.05)。结论:本研究尚未发现内蒙古地区人群中XRCC1的基因Arg194Trp多态性与肾癌的发病有相关性。
Objective: To investigate the relationship between human DNA repair gene XRCC1 Arg194Trp single nucleotide polymorphism and susceptibility to renal cell carcinoma in Inner Mongolia. Methods: Polymerase chain reaction-restriction fragment length polymorphism was used to detect the polymorphism of XRCC1 194 gene in 76 patients with renal cell carcinoma and 82 normal controls. Analysis of the relationship between genotype and renal cell carcinoma. Results: The genotype frequency of Arg / Arg50%, Arg / Trp38%, Trp / Trp12% in XRCC1194 renal cancer group was 56%, Arg / Arg34%, Trp / Trp10% There was no difference between the two groups (P> 0.05). Conclusion: This study has not found that there is a correlation between Arg194Trp polymorphism of XRCC1 gene and the incidence of renal cell carcinoma in Inner Mongolia.