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目的运用Meta分析的方法综合探讨TNF-α238位点基因多态性与尘肺病发病的相关性。方法通过计算机文献检索中国知网(CNKI)、万方数据资源和PubMed数据库,并结合文献追溯、网上查询的方法,收集所有关于TNF-α238位点基因多态性与尘肺易感性的病例对照研究。对符合条件的研究结果进行Meta分析,采用RevMan4.2软件计算合并比值比(OR)及95%的可信区间(95%CI)。结果共有在国内外发表的9篇文章纳入本次分析,病例组1 214人,对照组1 077人。经分析后,结果显示病例组和对照组中GA+AA基因型分布频率差异仍有统计学意义(P<0.05)。结论对目前相关研究结果的Meta分析显示,TNF-α238位点基因多态性与尘肺发生相关,携带GA+AA基因型的接尘工人发生尘肺的危险性较GG基因型明显增加;GA+AA基因型与尘肺病的发病严重程度有关。
Objective To analyze the association between TNF-α238 gene polymorphism and the incidence of pneumoconiosis using Meta-analysis. Methods The CNKI, Wanfang data sources and PubMed database were searched by computer. A case-control study on TNF-α238 gene polymorphism and susceptibility to pneumoconiosis was collected based on literature review and online search. . The results of eligible studies were analyzed by Meta-analysis and RevMan4.2 software was used to calculate the odds ratio (OR) and 95% confidence interval (95% CI). Results A total of 9 articles published at home and abroad were included in the analysis, including 1 214 cases and 1 077 controls. After analysis, the results showed that there was still a significant difference in the frequencies of GA + AA genotype between the case group and the control group (P <0.05). Conclusions Meta-analysis of the current research results shows that the polymorphism of TNF-α238 locus is associated with pneumoconiosis. The risk of pneumoconiosis in dust-exposed workers carrying GA + AA genotype is significantly higher than that of GG genotype. GA + AA Genotype and pneumoconiosis severity of the disease related.