论文部分内容阅读
过敏性紫癜是儿童常见的全身性血管炎性疾病。该病的病因可能涉及感染、遗传、药物、疫苗等方面。IgA1糖基化异常及分子清除障碍,导致IgA1免疫复合物介导的体液免疫异常;Th2和Th17细胞异常活化,IL-6、TNF-α分泌增多,TNF样凋亡弱化因子调控的核因子-κB活化,血浆一氧化氮、内皮素水平增高等细胞免疫和炎症介质的参与,可能共同导致微血管内皮损伤,促进过敏性紫癜的发生。
Henoch-Schonlein purpura is a common systemic vascular inflammatory disease in children. The etiology of the disease may involve infection, genetic, drugs, vaccines and so on. IgA1 glycosylation abnormalities and molecular disorders, resulting in IgA1 immune complex-mediated humoral immune abnormalities; Th2 and Th17 abnormal activation, increased secretion of IL-6, TNF-α, TNF-like apoptosis attenuated factor-regulated nuclear factor - κB activation, plasma nitric oxide, elevated endothelin levels and other cellular immune and inflammatory mediators may lead to microvascular endothelial injury, and promote the occurrence of allergic purpura.