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目的:探讨我院目前百草枯(Paraquat,PQ)中毒的治疗方法以及预后的危险因素分析。方法:对2009年5月～2011年8月的56例PQ中毒患者的临床资料进行回顾性分析,以生存组与死亡组为研究对象,比较2组口服药物的剂量的差异性,气管插管、机械通气时间、血液灌流、入院后24小时白细胞计数(WBC)、血清肌酐清除率(Crea)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、动脉血氧分压(MAP)与预后的关系。结果:56例中9例生存,47例死亡,病死率83.9%。口服药物的剂量与Crea与死亡率呈正相关(P<0.05),ALT、AST、MAP比较不具有统计学意义(P≥0.05)。结论:百草枯中毒患者的病死率极高,与服药量与早期肾功能改变相关,必须早期采用综合的治疗方法。
Objective: To investigate the treatment of paraquat (PQ) poisoning in our hospital and the risk factors of prognosis. Methods: The clinical data of 56 patients with PQ poisoning from May 2009 to August 2011 were retrospectively analyzed. The difference between the two groups of oral drug doses was compared between the survival group and the death group. The endotracheal intubation , Mechanical ventilation time, hemoperfusion, white blood cell count (WBC), Crea, ALT, MAP and prognosis relationship. Results: Nine of 56 patients survived and 47 died. The mortality rate was 83.9%. The dose of oral drug was positively correlated with Crea and mortality (P <0.05), while ALT, AST and MAP were not statistically significant (P> 0.05). Conclusion: The mortality rate of paraquat poisoning patients is very high, and the dose and early renal function related changes, we must adopt an early comprehensive treatment.