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目的研究雾化吸入高剂量糖皮质激素,治疗急性发作期儿童哮喘的临床效果。方法将深圳市南山区人民医院70例急性发作期哮喘患儿随机分为观察组与对照组,两组各35例,观察组采取雾化吸入高剂量糖皮质激素治疗,对照组口服醋酸泼尼松片,另均辅助异丙托溴铵混合液治疗,比较两组临床疗效及HR、RR、FEV1、PEF、SpO2数值治疗前后变化。结果观察组总有效率94.29%与对照组74.29%比较,差异有统计学意义(P<0.05);观察组治疗后HR、RR分别为(81.98±1.85)次/min、(26.76±3.05)次/min与对照组(93.44±2.12)次/min、(33.04±2.76)次/min比较,差异有统计学意义(P<0.05),FEV1、PEF、SpO2分别为(1.82±0.76)L、(150.63±15.95)L/min、(98.15±2.03)%与对照组(1.41±0.63)L、(123.95±14.03)L/min、(95.03±0.91)%比较,差异有统计学意义(P<0.05)。结论雾化吸入高剂量糖皮质激素治疗急性发作期儿童哮喘疗效明确,可缓解哮喘改善呼吸及体征指标,具有较高的临床应用价值。
Objective To study the clinical effect of inhalation of high dose glucocorticoid on asthma in children with acute exacerbation. Methods Seventy patients with acute exacerbation of asthma in Nanshan People’s Hospital of Shenzhen were randomly divided into observation group and control group, with 35 cases in each group. The observation group was treated with nebulized high-dose glucocorticosteroid. In the control group, oral prednisolone Song tablets, the other were treated with ipratropium bromide mixture, the two groups were compared the clinical efficacy and HR, RR, FEV1, PEF, SpO2 values before and after treatment changes. Results The total effective rate of observation group was 94.29% compared with 74.29% of control group, the difference was statistically significant (P <0.05). The HR and RR of observation group were (81.98 ± 1.85) / (26.76 ± 3.05) times / min and control group (93.44 ± 2.12) / min, (33.04 ± 2.76) / min, the difference was statistically significant (P <0.05), FEV1, PEF and SpO2 were (1.82 ± 0.76) L, 150.63 ± 15.95) L / min, (98.15 ± 2.03)% and (1.41 ± 0.63) L, (123.95 ± 14.03) L / min and (95.03 ± 0.91)%, respectively ). Conclusion Inhalation of high dose glucocorticoid inhaled asthma in children with acute exacerbation of a clear effect, can alleviate asthma to improve respiratory and physical indicators, has a high clinical value.