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用随机分组 ,前后自身对比设计方法观察了 18例NIDDM患者单用碳酸锂和美吡达及碳酸锂加美吡达治疗前后FBG ,FINS ,SI,SG ,KG ,Iarea0～ 2 0min的变化 ,发现单独用碳酸锂对上述指标无改善 ,单用美吡达可便FBG降低 ,KG ,SI ,Iarea0～ 2 0min增加 ,碳酸锂加美吡达后KG ,SI,Iarea0～ 2 0min也增加 ,与单用美吡达比较无明显差异 (P >0 .0 5 )。结果提示美吡达有改善胰岛素敏感性及胰岛 β细胞功能的双重作用 ,碳酸锂可加强美吡达的作用
The changes of FBG, FINS, SI, SG, KG, Iarea 0 ~ 20min in 18 NIDDM patients treated with Lithium carbonate alone and Piradaine and Lithium carbonate plus gypsum were observed by randomized comparison and before and after self-contrast design. Lithium carbonate did not improve the above indicators, with only the United States Pida FBG can be reduced, KG, SI, Iarea 0 ~ 20min increased, lithium carbonate plus gypsum KG, SI, Iarea 0 ~ 20min also increased, There was no significant difference between the two groups (P> 0.05). The results suggest that meperidine has the dual effect of improving insulin sensitivity and pancreatic β-cell function, and lithium carbonate may enhance the action of mepipa