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目的：探讨血清中糖类抗原19-9（CA19-9）、甲壳质酶蛋白-40（YkL-40）及蛋白激酶（AkT）水平在诊断子宫内膜肿瘤中联合检测的临床应用价值。方法选取100例子宫内膜肿瘤患者为观察组，另收集同期进入我院体检的健康者100例为健康组，分别检测2组血清CA19-9、YkL-40及AkT水平，比较各血清指标对诊断子宫内膜肿瘤的敏感度、特异度和准确度。结果观察组血清CA19-9、YkL-40及AkT水平较健康组显著性增高（P＜0.05）；CA19-9、YkL-40及AkT联合检测敏感度、特异度和准确度较各指标单独检测显著增高（ P ＜0.05），敏感度可达94.0％，特异度可达96.0％，准确度可提高至95.0％。结论血清中CA19-9、YkL-40及AkT水平与子宫内膜肿瘤显著相关，联合3项指标进行检测子宫内膜肿瘤具有较高的敏感度、特异度和准确度，能更好的辅助临床对子宫内膜肿瘤的诊断。“,”Objective To explore the diagnostic value in clinical application of the serum CA19-9,YkL-40 and AkT for endometrial tumors. Methods 100 patients with endometrial carcinoma were selected as observation group,and 100 health-y people as health group. To test CA19-9,YkL-40 and AkT levels in serum of two groups,and compared those three indexes of serum for the diagnostic sensitivity,specificity and accuracy of endometrial carcinoma. Results CA19-9,YkL-40 and AkT levels in serum of observation group were higher than their levels in the healthy group significantly(P<0. 05);CA19-9,YkL-40 and AkT Combined diagnosis sensitivity,specificity and accuracy were higher than used every index alone(P<0. 05). The sensitivity of 94. 0%,specificity of 96. 0%,the accuracy can be improved to 95. 0%. Conclusion CA19-9,YkL 40 and AkT levels in serum significant correlated with endometrial tumor. Combined three indicators for detecting endometrial cancer can improve the accuracy and sensitivity,and it can assist clinical diagnosis of endometrial carcinoma.