研究了铜催化条件下,酮肟的衍生物与苄烯丙二腈的环化反应,考察不同的催化剂、溶剂、添加剂等对反应的影响,成功的构建了一系列的2-氨基吡啶骨架化合物.并对苯乙酮肟以及苄烯丙二腈芳环上不同位置具有不同性质取代基的底物进行了拓展,以31%~81%的收率分离得到相应的目标产物,反应具有较好的底物普适性. The effects of different catalysts, solvents and additives on the reaction were studied under the copper-catalyzed cyclization reaction of ketoxime derivatives with benzylmalononitrile. A series of 2-aminopyridine skeleton compounds .And acetophenone oxime and benzyldinonitrile aryl ring different positions with different substituents on the substrate has been expanded to 31% to 81% yield isolated the corresponding target product, the reaction is better Substrate universality.