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许多研究表明,高胰岛素血症和胰岛素抵抗是肥胖症、葡萄糖耐量低减和轻度非胰岛素依赖型糖尿病的显著特征,而胰岛素抵抗可能又继发于高胰岛素血症。有的作者发现,在长期用胰岛素治疗的胰岛素依赖型糖尿病患者中,许多人也有高胰岛素血症和胰岛素抵抗,故高胰岛素血症可能也是此类患者发生胰岛素抵抗的因素之一。为更清楚地观察高胰岛素血症单一因素对靶细胞胰岛素作用的影响,本研究给正常大鼠皮下注射胰岛素使其产生高胰岛素血症,然后测定大鼠脂肪细胞膜特异结合胰岛素百分率和脂肪细胞葡萄糖氧化。
Numerous studies have shown that hyperinsulinemia and insulin resistance are prominent features of obesity, impaired glucose tolerance and mild non-insulin-dependent diabetes, and insulin resistance may be secondary to hyperinsulinemia. Some authors found that many people with insulin-dependent diabetes mellitus who have long-term insulin therapy also have hyperinsulinemia and insulin resistance, and hyperinsulinism may also be one of the factors that cause insulin resistance in such patients. In order to observe the effects of a single factor of hyperinsulinemia on the insulin sensitivity of target cells, we hypodermically inoculate insulin into hyperinsulinemia in normal rats, and then determine the percentage of insulin-specific lipids and adipocytes in rats Oxidation.