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目的研究襄阳地区女性人乳头瘤病毒(HPV)的感染现状及其与年龄的相关性。方法选取2012年7月-2016年7月在该院妇科门诊就诊7 411例女性,10 008份宫颈脱落细胞标本进行HPV定性检测,结合年龄信息进行统计分析。结果(1)10 008份标本中,HPV阳性标本2 649例,阳性率为26.47%;在不同年龄分组中,≥56岁感染率最高,占38.32%。(2)1163例重复检查且两次检查时间间隔一年以上的患者中,持续感染比例以>51岁组(22.3%)最高,持续感染所占比例随年龄增长呈上升趋势。(3)不同年龄段患者感染HPV型组之间差异无统计学意义(P>0.05);在所有年龄段患者中均以单一A9亚型感染率最高。结论襄阳地区女性HPV感染具有明显的亚型和年龄分布异质性,提示宫颈癌的筛查及防治应同时考虑HPV分型和年龄因素。
Objective To investigate the status of female human papillomavirus (HPV) infection in Xiangyang and its relationship with age. Methods From July 2012 to July 2016, 7 411 women and 10 008 cervical exfoliated cells were selected for gynecological outpatient examination in our hospital for qualitative detection of HPV and statistical analysis combined with age information. Results (1) Of the 10 008 specimens, 2 649 were positive for HPV, the positive rate was 26.47%. In the age group, the highest infection rate was ≥56, accounting for 38.32%. (2) The proportion of persistent infection in 1163 patients (> 22.3%) was the highest among the 1163 repeat patients whose interval was more than one year. The proportion of persistent infection increased with age. (3) There was no significant difference in HPV infection between different age groups (P> 0.05). The infection rate of single A9 subtype was the highest in all age groups. Conclusion HPV infection in Xiangyang area has obvious subtypes and age distribution heterogeneity, suggesting that cervical cancer screening and prevention should take into account the HPV type and age factors.