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目的探讨H2受体拮抗剂和质子泵抑制剂(PPI)缓解急性胃黏膜损伤的时效性研究。方法对2008年1月-2010年1月在急诊科就诊的98例急性乙醇中毒后胃黏膜损伤患者,随机分为对照组50例,治疗组48例。常规给予休息、保暖,补液,维持水、电解质、酸碱平衡,维持循环功能等治疗基础上,对照组给予H2受体拮抗剂治疗,治疗组给予PPI治疗。通过观察急性胃黏膜损伤患者上消化道症状及体征,记录不同饮酒及饮酒量,并根据患者就诊时间及不同饮酒组治疗后上消化道症状完全缓解时间进行比较。结果治疗组上消化道症状缓解所需时间与对照组比较差异有统计学意义(P<0.001),不同饮酒组上消化道症状缓解时间上差异有统计学意义(P=0.000)。结论 PPI在缓解急性乙醇中毒所致胃黏膜损伤的时效上更明显,具有临床价值。
Objective To investigate the time-effectiveness of H2 receptor antagonists and proton pump inhibitors (PPI) in ameliorating acute gastric mucosal injury. Methods From January 2008 to January 2010, 98 patients with gastric mucosal injury after acute alcoholism were randomly divided into control group (n = 50) and treatment group (n = 48). Routinely given rest, warm, rehydration, to maintain water, electrolyte, acid-base balance, maintaining circulatory function and other treatment based on the control group was given H2 receptor antagonist treatment, the treatment group given PPI treatment. By observing the symptoms and signs of upper gastrointestinal tract in patients with acute gastric mucosal injury, different alcohol consumption and alcohol consumption were recorded and compared with the time of treatment and the complete remission time of upper gastrointestinal symptoms after treatment in different drinking groups. Results The time required for remission of upper gastrointestinal symptoms in the treatment group was significantly different from that in the control group (P <0.001). There was significant difference in the remission time of upper gastrointestinal symptoms among different drinking groups (P = 0.000). Conclusion PPI is more effective in relieving gastric mucosal injury caused by acute alcoholism and has clinical value.