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目的探讨大剂量糖皮质激素在治疗重症病毒性脑炎中的作用。方法大剂量糖皮质激素甲基强的松龙+传统疗法(A组)治疗重症病毒性脑炎12例与传统疗法(B组)治疗13例的疗效比较。结果 A组的治愈率为75%,病死率8.3%;B组的治愈率为61.5%,病死率为15.5%。A组与B组在发热,抽搐的疗程天数比较,P<0.05;A组与B组在意识障碍、肢体瘫痪、脑干颅神经损害恢复方面的疗程天数比较,P<0.01。结论大剂量激素在治疗重症病毒性脑炎中作用显著。
Objective To investigate the role of high-dose glucocorticoids in the treatment of severe viral encephalitis. Methods The efficacy of high-dose glucocorticoid methylprednisolone plus traditional therapy (group A) in the treatment of 12 patients with severe viral encephalitis compared with 13 patients treated with conventional therapy (group B) was compared. Results The cure rate of group A was 75% and the case fatality rate was 8.3%. The cure rate of group B was 61.5% and the case fatality rate was 15.5%. The number of days of fever and seizure in group A and group B was significantly lower than that of group B (P <0.05). The days of treatment in group A and group B were significantly shorter than those in group B (P <0.01). Conclusion High-dose hormones play a significant role in the treatment of severe viral encephalitis.