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目的观察芍甘多苷对CCl4亚急性肝损伤大鼠血清转氨酶、肝脏病理及肝脏炎性因子的影响。方法采用CCl4诱发大鼠亚急性肝损伤,然后灌胃给予不同剂量的芍甘多苷治疗,观察药物对血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、肝脏组织病理、肝脏一氧化氮(NO)、一氧化氮合酶(NOS)、诱导型一氧化氮合酶(iNOS)及前列腺素F1α(PGF1α)、血栓素B2(TXB2)的影响。结果芍甘多苷对CCl4诱发大鼠亚急性肝损伤升高的转氨酶有明显的降低作用,并使形态学上的肝细胞变性和坏死得到明显改善和恢复,能降低TXB2含量,升高PGF1α/TXB2比值;能降低NO含量和NOS活性。结论芍甘多苷有明显的肝脏保护作用,其机制与降低TXB2,升高PGF1α/TXB2比值,降低NO含量和NOS活性有关。
Objective To observe the effects of glycosides of Shaoginseng on serum aminotransferase, liver pathology and hepatic inflammatory factors in rats with CCl4 subacute liver injury. Methods Subacute hepatic injury was induced by CCl4 in rats, and then treated with different doses of glycosides of Gansuogong glycosides. The effects of drugs on serum ALT, AST, Histopathology, the effects of nitric oxide (NO), nitric oxide synthase (NOS), iNOS, PGF1α and TXB2. Results Shaogan glycosides significantly reduce the transaminases with elevated CCl4-induced acute sub-acute liver injury and degeneration and necrosis of the morphologically hepatocellular hepatocytes were significantly improved and restored, can reduce TXB2 content, increased PGF1α / TXB2 ratio; can reduce the NO content and NOS activity. CONCLUSION Shaogan glucosidase has obvious protective effect on liver. Its mechanism is related to reducing TXB2, increasing PGF1α / TXB2 ratio, decreasing NO content and NOS activity.