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目的:了解一氧化氮(NO)与内皮素(ET)在老年糖尿病(DM)及糖尿病肾病(DN)的发生和发展中的变化规律,探讨其临床意义。方法:采用硝酸还原法和放射免疫法对62例2型糖尿病患者和30例正常健康老年人分别测定血清NO和ET的水平。结果:糖尿病组血ET和NO水平均明显高于正常对照组(P<0.05)。但ET/NO两组无明显差异(P>0.05);DN组血ET和ET/NO明显高于NDN组(P<0.05),但血NO则低于NDN组(P<0.05);血ET与病程、血压、BUN、Cr、UAER呈正相关,NO与病程、血压、BUN、Cr、UAER呈负相关。结论:在老年DM及DN患者,血ET和NO可能构成了一对具有拮抗反应的血管活性物质,参与了其疾病发生和发展,动态检测血清NO和ET水平在一定程度上可作为评估老年DM及DN病情进展的指标。
Objective: To investigate the changes of nitric oxide (NO) and endothelin (ET) in the occurrence and development of senile diabetes mellitus (DM) and diabetic nephropathy (DN), and to explore its clinical significance. Methods: Nitric acid reduction and radioimmunoassay were used to determine the levels of serum NO and ET in 62 patients with type 2 diabetes mellitus and 30 healthy controls. Results: The levels of plasma ET and NO in diabetic patients were significantly higher than those in normal controls (P <0.05). But there was no significant difference between the two groups (P> 0.05). The levels of ET and ET in NO group were significantly higher than those in NDN group (P <0.05) There was a positive correlation between disease duration, blood pressure, BUN, Cr and UAER. NO was negatively correlated with duration, blood pressure, BUN, Cr and UAER. Conclusion: ET and NO in the elderly DM and DN patients may constitute a pair of antagonistic reaction vasoactive substances involved in the occurrence and development of the disease, dynamic detection of serum NO and ET levels can be used as a measure of the elderly DM And DN disease progression indicators.